일레알 나트륨/담즙산 공동수송체 (ASBT) 및 일레알 담즙산 운반체 (IBAT)로도 알려진 일레알 나트륨/담즙산 공동수송체는 사람에서 SLC10A2 [5] [6] 암호화되는 담즙산:나트륨 심포터 단백질이다.
ASBT/IBAT는 장구 브러시 경계막에서 발견되는 회장 내 에서 가장 많이 발현됩니다. 장간 [7] 순환 의 일부로 장에서 담즙산 , 특히 복합 담즙산을 처음 섭취하는 역할을 한다.
약물 표적으로서 IBAT를 억제하기 위한 몇 가지 약 이 개발 되고 있다. 변비 및 과민성 [8] 대장증후군 치료를 위해 개발 중인 엘로빅시바 와 비알코올성 지방간염 [9] volixibat 가 그것이다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000125255 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG000023073 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Wong MH, Rao PN, Pettenati MJ, Dawson PA (May 1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33". Genomics . 33 (3): 538–40. doi :10.1006/geno.1996.0233 . PMID 8661017 . ^ "Entrez Gene: SLC10A2 solute carrier family 10 (sodium/bile acid cotransporter family), member 2" .^ Dawson PA (2011). "Role of the intestinal bile acid transporters in bile acid and drug disposition" . Handbook of Experimental Pharmacology . 201 (201): 169–203. doi :10.1007/978-3-642-14541-4_4 . ISBN 978-3-642-14540-7 PMC 3249407 PMID 21103970 . ^ Acosta A, Camilleri M (July 2014). "Elobixibat and its potential role in chronic idiopathic constipation" . Therapeutic Advances in Gastroenterology . 7 (4): 167–75. doi :10.1177/1756283X14528269 . PMC 4107709 PMID 25057297 . ^ Chitnis D (2016-08-03), "FDA grants fast track status to volixibat" , Internal Medicine News Digital Network , retrieved 2016-08-14 .
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그룹별
SLC1 ~ 10
(1): (2): (3): (4): (5): (6): (7): (8): (9): (10):
SLC11–20
(11): (12): (13): (14): (15): (16): (17): (18): (19): (20):
SLC21~30
(21): (22): (23): (24): (25): (26): (27): (28): (29): (30):
SLC31~40
(31): (32): (33): (34): (35): (36): (37): (38): (39): (40):
SLC41~48
(41): (42): (43): (44): (45): (46): (47): (48):
