나트륨 의존성 종합비타민 운반체

SLC5A6
식별자
별칭	SLC5A6, SMVT, 솔루트 캐리어 패밀리 5 멤버 6, NERIB
외부 ID	OMIM: 604024 MGI: 2660847 호몰로진: 23277 GeneCard: SLC5A6
유전자 위치(인간)
쳇.	염색체 2 (인간)
끝	27,212,958 bp
유전자 위치(마우스)
쳇.	5번 염색체(쥐)
끝	31,195,268 bp
RNA 표현 패턴
	표현된 상단
	간 우엽; ; 망막색소 상피; ; 지방 조직; ; 고환;
	추가 참조 표현식 데이터
	추가 참조 표현식 데이터
유전자 온톨로지
분자함수	심포터 활동; 나트륨 함량 복합비타민 투과성 전달 물질 활동; GO:0022891 트랜섬브레인 트랜스포터 활동;
셀룰러 컴포넌트	방광막; 막의 적분 성분; 테두리 막을 솔질하다; 플라즈마 막; 플라스마 막의 적분 성분; 막으로 막다;
생물학적 과정	이온 수송; 나트륨 이온 수송; 바이오틴 수송; 판토텐산염 투과 수송; 트랜스엠브레인 수송; 바이오틴 대사 과정; 판토텐산염 대사 과정;
	출처:아미고 / 퀵고
직교체
	8884
	330064
	ENSG00000138074
	ENSMUSG00000006641
	Q9Y289
	Q5U4D8
	NM_021095
	NM_001177621; NM_001177622; NM_177870; NM_001360022
	NP_066918
	NP_001171092; NP_001171093; NP_808538; NP_001346951
	위키다타
인간 보기/편집	마우스 보기/편집

나트륨 의존성 멀티비타민 트랜스포터는 인체에서 SLC5A6 유전자에 의해 암호화된 단백질이다.^[5]^[6]^[7]

SMVT는 혈액뇌장벽에 있는 판토텐산(Vitamin B5)과 비오틴(Vitamin B7)의 운반체다.^[8]알파리포산과^[9] 요오드화물의 운반체이기도 하다.이러한 영양소의 수송은 경쟁력이^[10] 있으며, 주어진 영양소의 잉여는 수송기를 포화시키고 다른 영양소의 흡수를 막을 수 있다.

참조

^ ^a ^b ^c GRCh38: 앙상블 릴리스 89: ENSG00000138074 - 앙상블, 2017년 5월
^ ^a ^b ^c GRCm38: 앙상블 릴리스 89: ENSMUSG00000006641 - 앙상블, 2017년 5월
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, et al. (March 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". The Journal of Biological Chemistry. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.
^ Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, et al. (May 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". The Journal of Biological Chemistry. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.
^ "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".
^ Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (July 2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983. S2CID 37721695.
^ Quick M, Shi L (2015). "The sodium/multivitamin transporter: a multipotent system with therapeutic implications". Vitamins and Hormones. 98: 63–100. doi:10.1016/bs.vh.2014.12.003. PMC 5530880. PMID 25817866.
^ Chirapu SR, Rotter CJ, Miller EL, Varma MV, Dow RL, Finn MG (31 March 2013). "High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid". Current Topics in Medicinal Chemistry. 13 (7): 837–42. doi:10.2174/1568026611313070006. PMID 23578027.

추가 읽기

Prasad PD, Wang H, Huang W, Fei YJ, Leibach FH, Devoe LD, Ganapathy V (June 1999). "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter". Archives of Biochemistry and Biophysics. 366 (1): 95–106. doi:10.1006/abbi.1999.1213. PMID 10334869.
Zempleni J, Steven Stanley J, Mock DM (August 2001). "Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star". The Journal of Nutritional Biochemistry. 12 (8): 465–473. doi:10.1016/S0955-2863(01)00162-0. PMID 11834205.
Dey S, Subramanian VS, Chatterjee NS, Rubin SA, Said HM (March 2002). "Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT". Biochimica et Biophysica Acta. 1574 (2): 187–92. doi:10.1016/s0167-4781(02)00226-9. PMID 11955628.
Balamurugan K, Ortiz A, Said HM (July 2003). "Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system". American Journal of Physiology. Gastrointestinal and Liver Physiology. 285 (1): G73-7. doi:10.1152/ajpgi.00059.2003. PMID 12646417.
Balamurugan K, Vaziri ND, Said HM (April 2005). "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects". American Journal of Physiology. Renal Physiology. 288 (4): F823-31. doi:10.1152/ajprenal.00375.2004. PMID 15561972.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Luo S, Kansara VS, Zhu X, Mandava NK, Pal D, Mitra AK (2006). "Functional characterization of sodium-dependent multivitamin transporter in MDCK-MDR1 cells and its utilization as a target for drug delivery". Molecular Pharmaceutics. 3 (3): 329–39. doi:10.1021/mp0500768. PMC 2553563. PMID 16749865.
Reidling JC, Nabokina SM, Said HM (January 2007). "Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system". American Journal of Physiology. Gastrointestinal and Liver Physiology. 292 (1): G275-81. doi:10.1152/ajpgi.00327.2006. PMID 16959947.
Reidling JC, Said HM (April 2007). "Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo". American Journal of Physiology. Cell Physiology. 292 (4): C1305-12. doi:10.1152/ajpcell.00360.2006. PMID 17135299.

인간 염색체 2의 유전자에 관한 이 기사는 단조롭다.위키피디아를 확장하여 도울 수 있다.

[refGRCh38Ensembl-1] GRCh38: 앙상블 릴리스 89: ENSG00000138074 - 앙상블, 2017년 5월

[refGRCm38Ensembl-2] GRCm38: 앙상블 릴리스 89: ENSMUSG00000006641 - 앙상블, 2017년 5월

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9516450-5] Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, et al. (March 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". The Journal of Biological Chemistry. 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.

[pmid10329687-6] Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, et al. (May 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". The Journal of Biological Chemistry. 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.

[entrez-7] "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6".

[Uchida_2015-8] Uchida Y, Ito K, Ohtsuki S, Kubo Y, Suzuki T, Terasaki T (July 2015). "Major involvement of Na(+) -dependent multivitamin transporter (SLC5A6/SMVT) in uptake of biotin and pantothenic acid by human brain capillary endothelial cells". Journal of Neurochemistry. 134 (1): 97–112. doi:10.1111/jnc.13092. PMID 25809983. S2CID 37721695.

[9] Quick M, Shi L (2015). "The sodium/multivitamin transporter: a multipotent system with therapeutic implications". Vitamins and Hormones. 98: 63–100. doi:10.1016/bs.vh.2014.12.003. PMC 5530880. PMID 25817866.

[10] Chirapu SR, Rotter CJ, Miller EL, Varma MV, Dow RL, Finn MG (31 March 2013). "High specificity in response of the sodium-dependent multivitamin transporter to derivatives of pantothenic acid". Current Topics in Medicinal Chemistry. 13 (7): 837–42. doi:10.2174/1568026611313070006. PMID 23578027.

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나트륨 의존성 종합비타민 운반체

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