S1PR2 또는 S1P 로도2 알려진 스핑고신-1-인산 수용체 2 는 지질 신호 분자 스핑고신 1-인산염 (S1P)을 결합하는 G 단백질 결합 수용체 를 인코딩하는 인간 유전자 다.[5]
함수 이 단백질은 스핑고신 1-인산염 유도 세포 증식, 생존, 전사 활성화에 참여한다.[5] 뉴라이트 아웃성장 억제제인 노고아(RTN4)와도 상호작용하는 것으로 나타났다. [6]
참고 항목 참조 ^ a b c GRCh38: 앙상블 릴리스 89: ENSG00000267534 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리스 89: ENSMUSG000043895 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ a b "Entrez Gene: S1PR2, sphingosine-1-phosphate receptor 2" .^ Kempf A, Tews B, Arzt ME, Weinmann O, Obermair FJ, Pernet V, Zagrebelsky M, Delekate A, Iobbi C, Zemmar A, Ristic Z, Gullo M, Spies P, Dodd D, Gygax D, Korte M, Schwab ME, Schiavo G (14 January 2014). "The Sphingolipid Receptor S1PR2 Is a Receptor for Nogo-A Repressing Synaptic Plasticity" . PLOS Biology . 12 (1): e1001763. doi :10.1371/journal.pbio.1001763 PMC 3891622 PMID 24453941 . ^ Rust R, Grönnert L, Gantner C, Enzler A, Mulders G, Weber RZ, Siewert A, Limasale YDP, Meinhardt A, Maurer MA, Sartori AM, Hofer AS, Werner C, Schwab ME (9 July 2019). "Nogo-A targeted therapy promotes vascular repair and functional recovery following stroke" . Proceedings of the National Academy of Sciences . 116 (28): 14270–14279. doi :10.1073/pnas.1905309116 PMC 6628809 PMID 31235580 . ^ Rust R, Grönnert L, Weber RZ, Mulders G, Schwab ME (September 2019). "Refueling the Ischemic CNS: Guidance Molecules for Vascular Repair". Trends in Neurosciences . 42 (9): 644–656. doi :10.1016/j.tins.2019.05.006 . PMID 31285047 . S2CID 195834057 . 추가 읽기 Spiegel S (2000). "Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors". Ann. N. Y. Acad. Sci . 905 (1): 54–60. Bibcode :2000NYASA.905...54S . doi :10.1111/j.1749-6632.2000.tb06537.x . PMID 10818441 . S2CID 9257870 . Takuwa Y (2002). "[Regulation of Rho family G proteins and cell motility by the Edg family of sphingosin 1-phosphate receptors]". Tanpakushitsu Kakusan Koso . 47 (4 Suppl): 496–502. PMID 11915348 . MacLennan AJ, Browe CS, Gaskin AA, et al. (1994). 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"Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins" . J. Biol. Chem . 274 (39): 27351–8. doi :10.1074/jbc.274.39.27351 PMID 10488065 . An S, Zheng Y, Bleu T (2000). "Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5" . J. Biol. Chem . 275 (1): 288–96. doi :10.1074/jbc.275.1.288 PMID 10617617 . Himmel HM, Meyer Zu Heringdorf D, Graf E, et al. (2000). "Evidence for Edg-3 receptor-mediated activation of I(K.ACh) by sphingosine-1-phosphate in human atrial cardiomyocytes". Mol. Pharmacol . 58 (2): 449–54. doi :10.1124/mol.58.2.449 . PMID 10908314 . Hla T (April 2001). "Sphingosine 1-phosphate receptors". Prostaglandins . 64 (1–4): 135–142. doi :10.1016/s0090-6980(01)00109-5 . PMID 11331101 . Mazurais D, Robert P, Gout B, et al. (2002). "Cell type-specific localization of human cardiac S1P receptors" . J. Histochem. Cytochem . 50 (5): 661–70. doi :10.1177/002215540205000507 PMID 11967277 . Osada M, Yatomi Y, Ohmori T, et al. (2003). "Enhancement of sphingosine 1-phosphate-induced migration of vascular endothelial cells and smooth muscle cells by an EDG-5 antagonist". Biochem. Biophys. Res. Commun . 299 (3): 483–7. doi :10.1016/S0006-291X(02)02671-2 . PMID 12445827 . Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903. Bibcode :2002PNAS...9916899M . doi :10.1073/pnas.242603899 PMC 139241 PMID 12477932 . Vogler R, Sauer B, Kim DS, et al. (2003). "Sphingosine-1-phosphate and its potentially paradoxical effects on critical parameters of cutaneous wound healing" . J. Invest. Dermatol . 120 (4): 693–700. doi :10.1046/j.1523-1747.2003.12096.x PMID 12648236 . 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