갈라닌수용체

Galanin receptor
갈라닌 수용체 1
식별자
기호GALR1
Alt. 기호GALNR1, GALNR
엔씨비유전자2587
HGNC4132
오밈600377
RefSeqNM_001480
유니프로트P47211
기타자료
로커스18번 씨 q23
갈라닌 수용체 2
식별자
기호GALR2
엔씨비유전자8811
HGNC4133
오밈603691
RefSeqNM_003857
유니프로트O43603
기타자료
로커스17번 씨 Q25.3
갈라닌 수용체 3
식별자
기호GALR3
엔씨비유전자8484
HGNC4134
오밈603692
RefSeqNM_003614
유니프로트O60755
기타자료
로커스22번 씨 Q12.2-13.1

갈라닌 수용체는 G단백질 결합 수용체, 즉 갈라닌을 결합하는 메타보틱 수용체다.[1]null

갈라닌 수용체는 말초신경계와 중추신경계, 내분비계 전반에서 발견된다.지금까지 세 가지 아형이 존재하는 것으로 알려져 있는데, GAL-R1, GAL-R2, GAL-R3이다.[2]2009년 현재 수용체 아형별 녹아웃 생쥐의 생성과 [3][4]갈란인 수용체 아형에 대한 최초의 선택적 리간드(ligands)와 관련하여 현재 큰 진전이 이루어지고 있지만, 각 아형의 구체적인 기능은 완전하게 해명되어야 한다.선택적 갈라닌 작용제는 항경련제인 반면,[5][6][7] 길항제들은 동물들에게 항우울제와 항불안제 효과를 생산하기 때문에 [8][9][10][11][12]갈라닌 수용체를 위한 작용제나 길항제 리간드는 인간에게 잠재적으로 치료적 화합물이 될 수 있다.null

리간즈

고민자

비선택적
GAL1 선택


GAL1/2 선택
  • M1154 - GalR3 상호[19] 작용 없음
GAL2 선택
  • 갈라닌 2-11 아마이드 - AR-M 1896이라고도 하며 마우스에서는 항경련제, CAS# 367518-31-8
  • M1145 - GalR1 및 GalR3과 비교하여 선택적임
  • M1153 - GalR1 및 GalR3와[21] 비교했을 때 선택적임
  • CYM 2503(양성 알로스테릭 모듈레이터)[22]

반목자

비선택적
  • M35 펩타이드
GAL1 선택
GAL2 선택
  • M871 펩타이드[18]
GAL3 선택

참조

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  2. ^ Branchek TA, Smith KE, Gerald C, Walker MW (2000). "Galanin receptor subtypes". Trends Pharmacol. Sci. 21 (3): 109–17. doi:10.1016/S0165-6147(00)01446-2. PMID 10689365.
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  18. ^ a b Sollenberg UE, Runesson J, Sillard R, Langel U (March 2010). "Binding of Chimeric Peptides M617 and M871 to Galanin Receptor Type 3 Reveals Characteristics of Galanin Receptor–Ligand Interaction". International Journal of Peptide Research and Therapeutics. 16 (1): 17–22. doi:10.1007/s10989-009-9197-9. S2CID 36850989.
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