호모 사피엔스 종의 단백질 코드 유전자
NR2C2 식별자 에일리어스 NR2C2 외부 ID OMIM : 601426 MGI : 1352466 HomoloGene : 2475 GeneCard: NR2C2 유전자 존재론 분자 함수 배열특이적 DNA결합 DNA결합 GO:0001131, GO:000115, GO:0001130, GO:0001204 DNA결합전사인자액티비티 GO:0001105 트랜스크립션코액티베이터 액티비티 아연 이온 결합 금속 이온 결합 스테로이드 호르몬 수용체 활성 GO:0001948 단백질 결합 단백질 헤테로다이머화 활성 RNA중합효소II전사조절영역배열특이적DNA결합 GO:0000980 RNA중합효소II 시스조절영역배열특이적 DNA결합 GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA결합전사활성화제, RNA중합효소II 특이적 GO:0001200, GO:0001133, GO:0001201 DNA결합전사인자활성, RNA중합효소II 특이적 시그널링수용체활성 셀룰러 컴포넌트 생물학적 과정 출처: 아미고 / QuickGO
맞춤법 종. 인간 마우스 엔트레즈 앙상블 유니프로트 RefSeq(mRNA) RefSeq(단백질) 장소(UCSC) Chr 3: 14.95 ~15.05 Mb Chr 6: 92.07 ~92.15 Mb PubMed 검색[3] [4] 위키데이터
고환수용체 4는 NR2C2([5] [6] [7] NR2C2 유전자에 의해 사람에게서 암호화되는 단백질 이다.
고환수용체 4는 전사인자 의 핵수용체 패밀리의 구성원이다.
상호 작용 고환 수용체 4는 다음과 상호작용하는 것 으로 나타났다.
「 」를 참조해 주세요. 레퍼런스 ^ a b c GRCh38: 앙상블 릴리즈 89: ENSG00000177463 - 앙상블 , 2017년 5월^ a b c GRCm38: 앙상블 릴리즈 89: ENSMUSG00000005893 - 앙상블 , 2017년 5월^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Entrez Gene: NR2C2" .^ Chang C, Da Silva SL, Ideta R, Lee Y, Yeh S, Burbach JP (Jun 1994). "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily" . Proceedings of the National Academy of Sciences of the United States of America . 91 (13): 6040–4. Bibcode :1994PNAS...91.6040C . doi :10.1073/pnas.91.13.6040 PMC 44133 PMID 8016112 . ^ Yoshikawa T, DuPont BR, Leach RJ, Detera-Wadleigh SD (Jul 1996). "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics . 35 (2): 361–6. doi :10.1006/geno.1996.0368 . PMID 8661150 . ^ Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (Dec 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily" . Proceedings of the National Academy of Sciences of the United States of America . 96 (26): 14724–9. Bibcode :1999PNAS...9614724L . doi :10.1073/pnas.96.26.14724 PMC 24715 PMID 10611280 . ^ Shyr CR, Hu YC, Kim E, Chang C (Apr 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells" . The Journal of Biological Chemistry . 277 (17): 14622–8. doi :10.1074/jbc.M110051200 PMID 11844790 . ^ Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (Mar 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4" . The Journal of Biological Chemistry . 278 (11): 9353–60. doi :10.1074/jbc.M205944200 PMID 12522137 .
추가 정보 Hirose T, Fujimoto W, Tamaai T, Kim KH, Matsuura H, Jetten AM (Dec 1994). "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily" . Molecular Endocrinology . 8 (12): 1667–80. doi :10.1210/mend.8.12.7708055 . PMID 7708055 . Young WJ, Smith SM, Chang C (Jan 1997). "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily" . The Journal of Biological Chemistry . 272 (5): 3109–16. doi :10.1074/jbc.272.5.3109 PMID 9006963 . Lee CH, Chinpaisal C, Wei LN (Sep 1998). "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4" . The Journal of Biological Chemistry . 273 (39): 25209–15. doi :10.1074/jbc.273.39.25209 PMID 9737983 . Lee YF, Shyr CR, Thin TH, Lin WJ, Chang C (Dec 1999). "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily" . Proceedings of the National Academy of Sciences of the United States of America . 96 (26): 14724–9. Bibcode :1999PNAS...9614724L . doi :10.1073/pnas.96.26.14724 PMC 24715 PMID 10611280 . Wang X, Yeh S, Wu G, Hsu CL, Wang L, Chiang T, Yang Y, Guo Y, Chang C (Nov 2001). "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells" . The Journal of Biological Chemistry . 276 (44): 40417–23. doi :10.1074/jbc.M104765200 PMID 11509567 . Yeung KC, Rose DW, Dhillon AS, Yaros D, Gustafsson M, Chatterjee D, McFerran B, Wyche J, Kolch W, Sedivy JM (Nov 2001). "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation" . Molecular and Cellular Biology . 21 (21): 7207–17. doi :10.1128/MCB.21.21.7207-7217.2001 . PMC 99896 PMID 11585904 . Shyr CR, Hu YC, Kim E, Chang C (Apr 2002). "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells" . The Journal of Biological Chemistry . 277 (17): 14622–8. doi :10.1074/jbc.M110051200 PMID 11844790 . Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD (Jul 2002). "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer" . The EMBO Journal . 21 (13): 3434–42. doi :10.1093/emboj/cdf340 . PMC 126089 PMID 12093744 . Yang Y, Wang X, Dong T, Kim E, Lin WJ, Chang C (Feb 2003). "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation" . The Journal of Biological Chemistry . 278 (9): 7709–17. doi :10.1074/jbc.M207116200 PMID 12486131 . Lin WJ, Li J, Lee YF, Yeh SD, Altuwaijri S, Ou JH, Chang C (Mar 2003). "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4" . The Journal of Biological Chemistry . 278 (11): 9353–60. doi :10.1074/jbc.M205944200 PMID 12522137 . Takaesu G, Surabhi RM, Park KJ, Ninomiya-Tsuji J, Matsumoto K, Gaynor RB (Feb 2003). "TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway". Journal of Molecular Biology . 326 (1): 105–15. doi :10.1016/S0022-2836(02)01404-3 . PMID 12547194 . Inui S, Lee YF, Chang E, Shyr CR, Chang C (Feb 2003). "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes". Journal of Dermatological Science . 31 (1): 65–71. doi :10.1016/S0923-1811(02)00152-4 . PMID 12615366 . Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K (Dec 2003). "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling" . The EMBO Journal . 22 (23): 6277–88. doi :10.1093/emboj/cdg605 . PMC 291846 PMID 14633987 . Cheung PC, Nebreda AR, Cohen P (Feb 2004). "TAB3, a new binding partner of the protein kinase TAK1" . The Biochemical Journal . 378 (Pt 1): 27–34. doi :10.1042/BJ20031794 . PMC 1223947 PMID 14670075 . Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G (Feb 2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology . 6 (2): 97–105. doi :10.1038/ncb1086 . PMID 14743216 . S2CID 11683986 .
외부 링크
(1) 기본 도메인
(1.1 ) 베이직 류신 지퍼(bZIP )(1.2) 기본나선-루프-나선 (bHLH )
그룹 A 그룹 B 그룹 C bHLH-PAS 그룹 D 그룹 E 그룹 F bHLH-COE
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) 기본나선경간나선(bHSH)
(2.1) 핵수용체 (CYS4 )
서브패밀리 1 서브패밀리 2 서브 패밀리 3 서브패밀리 4 서브패밀리 5 서브패밀리 6 서브패밀리 0
(2.2) 기타 CY4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) 교대 조성 (2.6) WRKY
