NFKB1

NFKB1
NFKB1
Protein NFKB1 PDB 1bfs.png
사용 가능한 구조
PDBOrtholog 검색: PDBe RCSB
식별자
에일리어스NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50, CVID12, 핵인자 Kappa B-1, NF-k 서브유닛
외부 IDOMIM: 164011 MGI: 97312 HomoloGene: 2971 GeneCard: NFKB1
맞춤법
종.인간마우스
엔트레즈

4790

18033

앙상블

ENSG00000109320

ENSMUSG000028163

유니프로트

P19838

P25799

RefSeq(mRNA)

NM_008689

RefSeq(단백질)

NP_032715

장소(UCSC)Chr 4: 102.5 ~102.62 MbChr 3: 135.29 ~135.4 Mb
PubMed 검색[3][4]
위키데이터
인간 보기/편집마우스 표시/편집

핵인자 NF-kappa-B p105 서브유닛은 사람에게서 NFKB1 유전자에 [5]의해 암호화되는 단백질이다.

이 유전자는 26S 프로테아솜에 의한 동시번역처리가 가능한 105kD 단백질을 암호화하여 50kD 단백질을 생성한다.105kD 단백질은 Rel 단백질 특이 전사 억제제이며 50kD 단백질은 NF-kappaB(NF-δB) 단백질 복합체의 DNA 결합 서브유닛이다.NF-δB는 사이토카인, 무산화라디칼, 자외선 조사, 세균 또는 바이러스 제품 등 다양한 세포내 및 세포외 자극에 의해 활성화되는 전사 인자이다.활성화된 NF-δB는 핵으로 전이되어 다양한 생물학적 기능에 관여하는 유전자의 발현을 자극한다; 200개 이상의 알려진 유전자는 특정 조건에서 다양한 세포 유형에서 NF-δB의 표적이다.NF-γB의 부적절한 활성화는 다수의 염증성 질환과 관련되며, NF-γB의 지속적 억제는 부적절한 면역 세포 발달 또는 세포 성장을 [6]지연시킨다.

모델 유기체

Nfkb1 녹아웃쥐 표현형

모델 유기체는 NFKB1 기능의 연구에 사용되어 왔다.Nfkb1이라고tm1a(KOMP)Wtsi[14][15] 불리는 조건부 녹아웃 마우스 라인이 International Knockout Mouse Consortium 프로그램의 일부로 생성되었습니다.이것은 질병 동물 모델을 생성하고 관심 있는 [16][17][18]과학자들에게 배포하는 높은 처리량 돌연변이 유발 프로젝트입니다.

수컷과 암컷은 표준화된 표현형 검사를 통해 [12][19]결실의 효과를 확인했습니다.돌연변이 생쥐에 대해 25개의 검사가 수행되었고 6개의 유의한 이상이 [12]관찰되었다.여성 호모 접합체는 호흡량 감소, 순환 알칼리 포스파타아제 수치 증가, 백혈구 세포수 증가 등을 보였다.남성 호모 접합자는 살모넬라균 감염에 대한 감수성이 높아진 반면, 양성 호모 접합자는 IgG1을 감소시키고 조절 T 세포와 NK 세포 [12]수를 감소시켰다.

상호 작용

NFKB1은 다음과 상호작용하는 것으로 나타났습니다.

레퍼런스

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추가 정보

외부 링크

이 기사에는 미국 국립 의학 도서관(미국 국립 의학 도서관)의 공공 도메인 텍스트가 포함되어 있습니다.